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Retatrutide 20 mg – Jolt Peptides vial and box
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Retatrutide 20 mg

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Analytical documentation

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What Retatrutide is

Retatrutide (development code LY3437943) is a synthetic peptide that activates three receptors at once: the receptors for GIP, GLP-1 and glucagon. That is why it is often called a triple agonist. It is an investigational substance and is not an approved medicinal product.

What is studied with Retatrutide

  • Body weight and energy balance – a phase 2 trial published in 2023 reported marked weight loss in people with obesity; larger phase 3 programmes are ongoing.
  • Glucose metabolism – effects on blood sugar control in type 2 diabetes models and trials.
  • Liver fat – changes in fat stored in the liver.
  • Receptor pharmacology – how combining glucagon receptor activity with GIP/GLP-1 changes energy expenditure.

Reconstitution and storage

The vial contains 20 mg of lyophilized peptide. Dissolving it in 2.0 ml of solvent gives 10 mg/ml, i.e. 10 µg in every microlitre. The reconstitution calculator works out other volumes; for reconstitution we offer bacteriostatic water.

Store the lyophilisate dry and dark, long term at −20 °C. Keep the solution at 2–8 °C, divide it into aliquots for longer storage and avoid repeated thawing. More in how to store and ship peptides.

For laboratory research only. Not for human consumption.

Specifications

Substance

Retatrutide (LY3437943)

Code

LY3437943

CAS

2381089-83-2

Mechanism

GIP / GLP-1 / glucagon receptor agonist

Form

Lyophilized powder, 20 mg

Peptides in transit

We ship lyophilized peptides in glass vials by standard shipping; they do not need refrigeration. Short temperature fluctuations in transit do not reduce their quality, and the lyophilized form stays stable for several weeks even in summer temperatures.

Storing lyophilized peptides

Store lyophilized peptides in a dry place, protected from light and moisture. We generally recommend these conditions:

  • Room temperature (15–25 °C): up to 3 months
  • In the fridge (2–8 °C): up to 6 months
  • In the freezer (−20 °C and below): 3–5 years (recommended for long-term storage)

After taking the vial out of the fridge or freezer, let it warm to room temperature.

Storing reconstituted peptides

Peptide solutions are generally less stable after reconstitution than the lyophilized form, so keep them cold whenever possible. We generally recommend these conditions:

  • Room temperature (15–25 °C): not recommended long term
  • In the fridge (2–8 °C): usually 4–8 weeks
  • In the freezer (−20 °C and below): up to 3–4 months

To keep the peptide intact, avoid repeated freezing and thawing, which can speed up its degradation.

Important:

Most manufacturers recommend using reconstituted peptides stored at 2–8 °C within 4 weeks. This recommendation is deliberately cautious and may not reflect the actual chemical stability of every peptide. In our own stability tests, many peptides dissolved in bacteriostatic water showed no measurable degradation after 12 weeks in the fridge. Stability depends strongly on the sequence and formulation, however, so this result cannot be generalised to all peptides without more data.

Scientific sources and citations will appear here.

Every new formulation is based on data from reliable scientific sources:

PubChem chemical database logo
Science journal logo
Janoshik independent laboratory logo
LiquiLabs independent laboratory logo
Logo PubMed (National Library of Medicine)
PubChem chemical database logo
Science journal logo
Janoshik independent laboratory logo
LiquiLabs independent laboratory logo
Logo PubMed (National Library of Medicine)

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